Recurrent cytogenetic findings in subsets of patients with chronic lymphocytic leukemia expressing IgG-switched stereotyped immunoglobulins.

نویسندگان

  • Anastasia Athanasiadou
  • Kostas Stamatopoulos
  • Maria Gaitatzi
  • Niki Stavroyianni
  • Athanasios Fassas
  • Achilles Anagnostopoulos
چکیده

We report a remarkable association of recurrent (stereotyped) cytogenetic aberrations with two subsets of chronic lymphocytic leukemia (CLL) cases expressing IgG-switched, stereotyped B-cell receptors (BCRs). Comparison with cases with heterogeneous BCRs showed that these recurrent cytogenetic aberrations were subset-biased. These findings further support a role for antigen in CLL development.

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عنوان ژورنال:
  • Haematologica

دوره 93 3  شماره 

صفحات  -

تاریخ انتشار 2008